Royal Air Force Typhoon fighter aircraft have conducted a mission with French aircraft in a joint strike on an subterranean weapons facility in Syria operated by the IS group, as stated by the British defence ministry.
The location, located using reconnaissance, was thought to be housing weapons and explosive materials, the statement said, and was located in mountains just north of the ancient city of Palmyra in Syria's central region.
"Our aircraft used Paveway IV guided bombs to target a number of entry passages providing entry to the site... initial indications indicate the target was engaged successfully," the MoD said.
There was no indication of any civilian impact in the strike on Saturday evening and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were supported by a Voyager refuelling tanker.
IS - also known as ISIS - imposed militant control over parts of Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates the UK's leading role, and resolve to operate in unison with our allies, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the area," Britain's Defence Chief the Defence Secretary said.
RAF aircraft have performed overwatch operations over Syria to "prevent any efforts to regroup" of Islamic State after its military defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank the personnel of our armed forces who took part in this mission for their professionalism and their valour," the Defence Secretary added. "They were part of thousands of UK service members deployed over Christmas and New Year. This action, to eliminate terrorist threats who pose a risk to our safety, shows how British military are ready to step up, throughout the year, keeping Britain secure within its borders and influential overseas."
During December, the United States armed forces carried out what it called a "large-scale strike" targeting Islamic State objectives in Syria, after an ambush resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations reports Islamic State still boasts roughly 5-7 thousand fighters in Syria and Iraq.